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KMID : 0615720030200020077
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Jouranl of Korean Acupuncture and Moxibustion society
2003 Volume.20 No. 2 p.77 ~ p.84
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Effects of Bee Venom on the pain, edema, and acute inflammatory reactant of Rheumatoid Arthritis patients
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Abstract
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Objective : In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients.
Methods : Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender joint counts, swollen joint counts, Visual analog scale(VAS), morning in stiffness, ESR, C-reactive protein(CRP) were analyzed before and after BV therapy.
Results : The results as follows:
1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy(9.0±7.9 vs 15±11.4, p=0.002).
2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy (5.0±6.1 vs 1.5±2.3, p=0.001).
3. VAS in patients after BV therapy was significantly lower than before BV therapy(60.8±17.6 vs 38.0±15.9, p=0.000).
4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy(119.1±112.6min vs 59.0±89.7 min, p=0.009).
5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect.
Conclusions: BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed in log-term effect of BV therapy.
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